Science and medicine has made vast headway in the development of synthetic compounds that can effectively be utilized as Testosterone boosters, which can provide effective treatment for those experiencing low Testosterone (hypogonadism and andropause). The compounds include the primary two categories:
- SERMs (Selective Estrogen Receptor Modulators)
- AIs (Aromatase Inhibitors)
Some of these synthetic compounds can be obtained legally over the counter (OTC) in supplement stores, and others are available via prescription-only. The difference between many of these compounds, whether or not they are prescription or OTC, is that of a variation in strength. There exist, for example, very strong aromatase inhibitors such as Femara (Letrozole), while there are more mild aromatase inhibitors such as 6-OXO (4-AT), which is available over the counter in many places in supplement stores.
SERMs: These are synthetic compounds that are generally non-steroidal in nature, and are instead commonly triphenylethylene compounds. They include products such as Nolvadex (Tamoxifen), Clomid (Clomiphene), Fareston (Toremifene), Evista (Raloxifene). All of these serve to block Estrogen at Estrogen’s objective receptor sites in various particular tissues (specifically breast tissue). This procedure is known as Estrogen antagonism, which is the terminology describing the Estrogen blocking activity of these compounds whereby they will bind to Estrogen’s target receptors and then essentially force Estrogen out of the receptor sites, or prevent Estrogen from being able to bind to its target receptor sites. This is what is known as Estrogen antagonism. In other tissues, they serve to function as Estrogen agonists, such as within liver tissue, where they exert Estrogenic effects on their own accord in these areas. Some positive effects can be seen from such effects, for example the positive cholesterol changes that Nolvadex (Tamoxifen) exhibits when it acts as an Estrogen agonist in the liver. Specifically for the purpose of acting as a Testosterone booster, many of these SERMs, to varying degrees, will function as Estrogen antagonists at receptors located at the pituitary gland, which will result in a stimulation of gonadotropin (LH and FSH release), and as a result, Testosterone levels will ultimately increase. SERMs are in fact used as a frequent treatment for HPTA recovery within medicine due to their Estrogen antagonistic actions on the pituitary gland, which consequently results in a Testosterone boosting effect through their process in causing stimulation of the Leydig cells of the testes.
AIs: Aromatase inhibitors are synthetic compounds, whereby some might be steroidal in nature and others might not be. These are compounds such as Aromasin (Exemestane), Arimidex (Anastrozole), Femara (Letrozole), and Proviron (Mesterolone) as well as many other compounds that can be available both OTC as well as prescription-only. Each of these compounds disable the cause of rising Estrogen levels at the root: aromatization. Aromatization, as previously mentioned in this article, is a metabolic process in which Testosterone (or any androgen with the capability of experiencing this procedure) is converted into Estrogen by means of contact with the aromatase enzyme. The aromatase enzyme is the sole cause for aromatization, and this enzyme will becomes inhibited (or disabled) by the aforementioned aromatase inhibitors. Some of these inhibitors will only disable the aromatase enzyme temporarily, such as Arimidex and Letrozole, while others will inhibit the enzyme permanently, such as Aromasin and 6-OXO (4-AT), which are known as suicidal inhibitors. Many of these aromatase inhibitors will vary in strength from very mild, such as Proviron, to very strong, such as Letrozole. In terms of their Testosterone boosting effects, AIs will adjust and stimulate the negative feedback loop of the HPTA by way of plummeting total blood plasma levels of Estrogen. As previously mentioned in this article, if excess Estrogen is detected in the bloodstream, the hypothalamus will respond through the negative feedback loop by way of signaling a reduction of Testosterone production, however, if Estrogen levels are unusually lower than standard physiological levels, it causes an antagonizing effect whereby the HPTA will generate higher levels of Testosterone. Studies have demonstrated the effectiveness of these compounds on boosting Testosterone, where some aromatase inhibitors have increased serum Testosterone levels in test subjects by 58% above baseline, while other studies on other aromatase inhibitors have increased it upwards of 60% or greater, and some as great as 84% and even 90%.
- SERMs (Selective Estrogen Receptor Modulators)
- AIs (Aromatase Inhibitors)
Some of these synthetic compounds can be obtained legally over the counter (OTC) in supplement stores, and others are available via prescription-only. The difference between many of these compounds, whether or not they are prescription or OTC, is that of a variation in strength. There exist, for example, very strong aromatase inhibitors such as Femara (Letrozole), while there are more mild aromatase inhibitors such as 6-OXO (4-AT), which is available over the counter in many places in supplement stores.
SERMs: These are synthetic compounds that are generally non-steroidal in nature, and are instead commonly triphenylethylene compounds. They include products such as Nolvadex (Tamoxifen), Clomid (Clomiphene), Fareston (Toremifene), Evista (Raloxifene). All of these serve to block Estrogen at Estrogen’s objective receptor sites in various particular tissues (specifically breast tissue). This procedure is known as Estrogen antagonism, which is the terminology describing the Estrogen blocking activity of these compounds whereby they will bind to Estrogen’s target receptors and then essentially force Estrogen out of the receptor sites, or prevent Estrogen from being able to bind to its target receptor sites. This is what is known as Estrogen antagonism. In other tissues, they serve to function as Estrogen agonists, such as within liver tissue, where they exert Estrogenic effects on their own accord in these areas. Some positive effects can be seen from such effects, for example the positive cholesterol changes that Nolvadex (Tamoxifen) exhibits when it acts as an Estrogen agonist in the liver. Specifically for the purpose of acting as a Testosterone booster, many of these SERMs, to varying degrees, will function as Estrogen antagonists at receptors located at the pituitary gland, which will result in a stimulation of gonadotropin (LH and FSH release), and as a result, Testosterone levels will ultimately increase. SERMs are in fact used as a frequent treatment for HPTA recovery within medicine due to their Estrogen antagonistic actions on the pituitary gland, which consequently results in a Testosterone boosting effect through their process in causing stimulation of the Leydig cells of the testes.
AIs: Aromatase inhibitors are synthetic compounds, whereby some might be steroidal in nature and others might not be. These are compounds such as Aromasin (Exemestane), Arimidex (Anastrozole), Femara (Letrozole), and Proviron (Mesterolone) as well as many other compounds that can be available both OTC as well as prescription-only. Each of these compounds disable the cause of rising Estrogen levels at the root: aromatization. Aromatization, as previously mentioned in this article, is a metabolic process in which Testosterone (or any androgen with the capability of experiencing this procedure) is converted into Estrogen by means of contact with the aromatase enzyme. The aromatase enzyme is the sole cause for aromatization, and this enzyme will becomes inhibited (or disabled) by the aforementioned aromatase inhibitors. Some of these inhibitors will only disable the aromatase enzyme temporarily, such as Arimidex and Letrozole, while others will inhibit the enzyme permanently, such as Aromasin and 6-OXO (4-AT), which are known as suicidal inhibitors. Many of these aromatase inhibitors will vary in strength from very mild, such as Proviron, to very strong, such as Letrozole. In terms of their Testosterone boosting effects, AIs will adjust and stimulate the negative feedback loop of the HPTA by way of plummeting total blood plasma levels of Estrogen. As previously mentioned in this article, if excess Estrogen is detected in the bloodstream, the hypothalamus will respond through the negative feedback loop by way of signaling a reduction of Testosterone production, however, if Estrogen levels are unusually lower than standard physiological levels, it causes an antagonizing effect whereby the HPTA will generate higher levels of Testosterone. Studies have demonstrated the effectiveness of these compounds on boosting Testosterone, where some aromatase inhibitors have increased serum Testosterone levels in test subjects by 58% above baseline, while other studies on other aromatase inhibitors have increased it upwards of 60% or greater, and some as great as 84% and even 90%.
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